Current projects:

Mass spectrometry-based quantification of 2,000-3,000 proteins by applying data-independent acquisition (DIA) methods on iPS cell-derived sub-proteomes (e.g. mitochondria. Identification of disease-associated pathways based on proteomic signatures specific to defined PD mutations.

Research focus:

Guilt-by-association” or a “Protein’s Facebook”: Learning from protein-protein interaction networks determined by affinity purification combined with quantitative mass spectrometry based on stable isotope labelling of amino acids in cell culture (SILAC) to identify specific interactors.

Furthermore:

• Analysis of protein networks and disease biomarkers
• Proteomics
• Mass spectrometry
• Biochemistry of disease proteins
• Molecular neuroscience, parkinson’s disease

Links: Publications on Pubmed, DZNE, Hertie Institute

Current members: Link to group members at DZNE