Projects:

• Isolation, cultivation and characterization of human and porcine stem cells
• Molecular biology techniques for performing the cell SELEX experiments, e.g. PCR, qRT-PCR, single-stranded DNA generation, gel electrophoresis, cloning, flow cytometry, and NGS
• Evaluation of the generated aptamers

Aptamers

Aptamers are short single-stranded RNA or DNA oligonucleotides (25-90 nucleotides). Their three-dimensional structure allows them to bind their target molecules with a high affinity and specificity. The enormous number of possible tertiary structures allows aptamers to recognize and bind small molecules, peptides, proteins or even complex structures, such as entire cells, bacteria or viruses.

Reseach focus:

Tissue engineering, Stem cells, Cardiomyocytes, Angiogenesis, Endothelialization, Biofunctionalization of implants and scaffolds, Hemocompatibility, Aptamers, Synthetic mRNA.

Links: Publications on Pubmed, Margarete von Wrangell Stiftung

Current members: Ludmilla Hann, Heidrun Steinle, Sonia Golombek, Marbod Weber, Leila Mohammadnejad