Current projects:

• Differentiation of iPS cells into patient specific neurons, “Brainoids” and hepatocytes
• Screen for compounds ameliorating the load of neurotoxic metabolites
• Explore potential therapeutic approaches by addressing affected pathways

Clinical neurogenetics:

• Ataxia – Hereditary Spastic Paraplegia – Motor neuron disease and frontotemporal dementia
• Leukodystrophies in adulthood
• Leukodystrophies in adulthood – Center for rare neurological diseases (Huntington disease, mitochondriopathies, etc.)

Research focus:

Modelling neurogenetic diseases using induced pluripotent stem cells and its differentiation into neurons which are genetically identical to our patients.

Links: Publications on Pubmed, Herti Institute for Brain Research – Section fo Clinical Neurogenetics